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Biochemistry 5

A 23-year-old man presents to a clinic within a medical compound in Nigeria. The compound is running a trial looking at whole-genome sequencing of pathogen in suspected infectious disease. He presents following 3-months of feeling hot and sweating at night, and he has recently noticed weight-loss and describes his trousers now slipping down to his hips. His medical history includes HIV which is treated with emtricitabine and tenofovir. He works as a local farmer. Physical examination reveals a thin, somewhat ill-appearing man. A sputum sample is obtained, and Ziehl-Neelsen staining shows acid-fast bacilli. Whole-genome sequencing shows a mutation in the rpoB gene, causing a change in the binding site of RNA polymerase, leading to a change in antibiotic prescription due to a concern of resistance.

To which of the following antibiotics is this pathogen most likely resistant?

  • A) Bedaquiline
  • B) Ethambutol
  • C) Isoniazid
  • D) Pyrazinamide
  • E) Rifampicin


Octavi Casals Farre


Dr. Ted O'Connell

Last updated

Jun 04, 2022

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