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Biochemistry 4

A 39-year-old man comes to the physician complaining of night sweats and low-grade fevers for the past two weeks. His past medical history includes asthma and allergic rhinitis. His father has diabetes mellitus type II, and his mother has systemic lupus erythematosus. He consumes an average of three beers per week and has smoked one pack of cigarettes per day for the past fourteen years. On further questioning, the patient admits he occasionally self-administers heroin injections on the weekends. His temperature is 37.8°C (100.1°F), blood pressure is 132/76 mmHg, heart rate is 75 beats/minute, and respirations are 17/minute. Physical examination is unremarkable. He undergoes p24 antigen testing and is ultimately diagnosed with HIV infection. His physician recommends initiation of antiretroviral therapy and prescribes a medication whose enzyme kinetics are shown in the Lineweaver-Burk plot below.

Based on the information provided in the plot (see figure below), which of the following antiretroviral drugs did the physician most likely prescribe?

  • A) Darunavir
  • B) Delavirdine
  • C) Didanosine
  • D) Dolutegravir
  • E) Zidovudine


Jonathan Barnett


Dr. Ted O'Connell