A 27-year-old woman presents to the emergency department with shortness of breath, cough, nausea, vomiting and fever for the past day. Her past medical history is notable for cystic fibrosis (CF), type 2 diabetes mellitus managed glargine insulin, chronic sinusitis, and CF-related pancreatic insufficiency. Due to worsening respiratory distress, the patient is intubated in the emergency department, and a bronchoalveolar lavage is performed which shows detectable influenza A infection. Sputum cultures prior to intubation grow mucoid pseudomonal pneumonia. CT scan of the chest shows diffuse bilateral peribronchovascular consolidative and nodular opacities on a background of ground-glass attenuation consistent with multifocal pneumonia.
What of the following is the best treatment choice in this patient?
- A) Cefepime
- B) Cefepime and oseltemivi
- C) Linezoli
- D) Oseltemivir
- E) Oseltemivir, linezolid, and cefepime
Dr. Raj Dasgupta