A 33-year-old man presents to the physician for a follow-up visit. Past medical history includes gastroesophageal reflux, peptic ulcer disease, and renal calculi. He says he has been doing well apart from some back and joint pain. Physical examination is notable for mild midline vertebral tenderness, but no joint swelling, redness, or significant pain is appreciated. Laboratory studies reveal an elevated serum calcium level. Further evaluation reveals primary hyperparathyroidism. He is referred for parathyroidectomy but declines surgery and is subsequently started on cinacalcet.
Which of the following is the mechanism of action of cinacalcet?
- A) Inhibits calcitriol production
- B) Inhibits osteoclast activation
- C) Inhibits osteoclast function
- D) Promotes calcium loss in the urine
- E) Sensitizes calcium-sensing receptors