A 43-year-old man presents to the emergency department with substernal chest pain that started during his usual Sunday morning walk two hours ago. He describes it as a pressure sensation and that it was alleviated by rest and nitroglycerin. He reports that his father and brother both passed away from myocardial infarctions at the age of 45 years. His medical history is significant for hypertension and hyperlipidemia. He takes atorvastatin for the hyperlipidemia. He started lisinopril 8 weeks ago and reports that he has had a dry nagging cough which started shortly after starting this medication. His vital signs are blood pressure 140/90 mmHg, temperature 98.9°F (37°C), pulse 102 beats/minute, and respirations 28/minute. A cardiac workup is initiated.
Which of the following is the mechanism of action of lisinopril?
- A) Inhibits HMG-CoA reductase in the synthesis of cholesterol
- B) Inhibits the conversion of angiotensin I to angiotensin II
- C) Stimulates the angiotensin II receptors to secrete aldosterone
- D) Stimulates the conversion of angiotensinogen to angiotensin I
- E) Stimulates the synthesis of bradykinins