Step 1

Musculoskeletal 1

A 29-year-old woman presents to her physician a complaint of fatigue for the last 3 weeks. She reports a mild febrile upper respiratory illness that resolved on its own about 4 weeks ago. Over the last few weeks, she has felt increasingly more fatigued. Upon further questioning, she notes morning joint stiffness in both of her hands that resolves after a few minutes. She denies any feelings of depression or anhedonia. Her past medical history is significant for two miscarriages. The only medicine she takes is acetaminophen for occasional headaches. Vital signs are within normal limits. Physical examination reveals mild conjunctival pallor, a morbilliform eruption with erythema, and edema of the hands that spares the joints.

Which of the following tests is most specific for this patient's condition?

  • A) Anti-double stranded DNA antibody assay
  • B) Antinuclear antibody assay
  • C) Anti-SS-A antibody assay
  • D) Anti-streptolysin O antibody assay
  • E) Rheumatoid factor


Ardian Latifi


Dr. Ted O'Connell

Last updated

Sep 08, 2022


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