Step 1

Biochemistry 9

A 37-year-old man presents to the physician complaining of night sweats and low-grade fevers for the past two weeks. He has a past medical history of asthma. His father has diabetes mellitus type II, and his mother has systemic lupus erythematosus. He consumes an average of three beers per week and has smoked one pack of cigarettes per day for the past fourteen years. He also reports that he occasionally self-administers heroin injections on the weekends. Vital signs are: temperature 37.8°C (100.1°F), blood pressure 132/76 mmHg, heart rate 75 beats/minute, and respirations 17/minute. Physical examination is unremarkable. He undergoes p24 antigen testing and is ultimately diagnosed with HIV. His physician recommends initiation of antiretroviral therapy and prescribes a medication whose enzyme kinetics are shown in the Lineweaver-Burk plot below.

Based on the information provided in the plot, which of the following antiretroviral drugs did the physician most likely prescribe?

  • A) Darunavir
  • B) Delavirdine
  • C) Didanosine
  • D) Dolutegravir
  • E) Zidovudine


Jonathan Barnett


Dr. Ted O'Connell